Our lab investigates how experience drives changes in brain function. We study this problem at several different levels in multiple contexts. Part of the lab studies how specific genes determine the plasticity of brain circuitry during development, what are these mechanisms of plasticity and how do they operate. The other part of the lab studies how these same genes that govern plasticity during development might function to regulate learning and memory. Some of the genes we study improve plasticity, for example a gene called nogo-66 receptor 1, while others, such as those implicated in syndromic forms of autism, impair plasticity during development.